An interoperable U.S. healthcare system depends on collaboration across diverse groups inside and outside of government, working in a complex environment toward a common goal. The Office of the National Coordinator for Health IT (ONC) and the Centers for Medicare & Medicaid Services (CMS) play different but complementary roles to advance health data interoperability. ONC and CMS each lead regulatory and programmatic efforts to evolve the interoperability landscape, collaborating closely with each other and industry groups – payers,