{"id":22256,"date":"2022-10-19T09:15:50","date_gmt":"2022-10-19T13:15:50","guid":{"rendered":"https:\/\/healthit-gov.go-vip.net\/buzz-blog\/?p=22256"},"modified":"2026-01-17T21:36:09","modified_gmt":"2026-01-17T21:36:09","slug":"ai-ml-in-health-care","status":"publish","type":"post","link":"https:\/\/healthit.gov\/blog\/ai-ml\/ai-ml-in-health-care\/","title":{"rendered":"Two Sides of the AI\/ML Coin in Health Care"},"content":{"rendered":"\n<p><span data-contrast=\"auto\">As we\u2019ve <\/span><a href=\"https:\/\/healthit.gov\/buzz-blog\/health-data\/minimizing-risks-and-maximizing-rewards-from-machine-learning\"><span data-contrast=\"none\">previously discussed<\/span><\/a><span data-contrast=\"auto\">, algorithms\u2014step by step instructions (rules) to perform a task or solve a problem, especially by a computer\u2014have been widely used in health care for decades.&nbsp; One clear use of these algorithms is through evidence-based, <\/span><a href=\"https:\/\/healthit.gov\/clinical-decision-support\/\"><span data-contrast=\"none\">clinical decision support interventions<\/span><\/a><span data-contrast=\"auto\"> (DSIs). Today, we see a rapid growth in data-based, predictive DSIs, which use models created using machine learning (ML) algorithms or other statistical approaches that analyze large volumes of real-world data (called \u201ctraining data\u201d) to find patterns and make recommendations. While both evidence-based and predictive DSI types (models) could be used to address the same problem, they rely on different logic that\u2019s \u201cbaked into\u201d their software.\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<p><span data-contrast=\"auto\">But before we explore the two approaches, we should first revisit a key challenge posed in our previous post in this series: capitalizing on the potential of artificial intelligence (AI), particularly ML and related technologies, while avoiding risks (such as potential harm to a patient) from these technologies. In this blog post, we\u2019ll dig a little deeper into what some of those risks are and where those risks can originate.&nbsp;&nbsp;<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-evidenced-based-vs-predictive-decision-support-interventions-nbsp\"><b><span data-contrast=\"none\">Evidenced-Based vs. Predictive Decision Support Interventions\u202f\u202f<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/h2>\n\n\n\n<p><span data-contrast=\"auto\">DSIs that <\/span><a href=\"https:\/\/academic.oup.com\/jamia\/article\/8\/6\/527\/778603\"><span data-contrast=\"none\">use evidence-based guidelines or other expert consensus<\/span><\/a><span data-contrast=\"auto\"> generate recommendations based on how the world <\/span><b><span data-contrast=\"auto\">should work<\/span><\/b><span data-contrast=\"auto\">. Generally,<\/span> <span data-contrast=\"auto\">they represent the implementation of expert consensus emerging from high-quality clinical trials, observational studies, and other research. Evidence-based DSIs are usually \u201cfixed rules,\u201d essentially, a series of \u201cif-then\u201d statements that form an algorithm. For instance, \u201cif a woman is between the age of 45-54 and if she is of average risk of breast cancer, then she should get a mammogram every year.\u201d\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<p><span data-contrast=\"auto\">Predictive DSIs, by contrast, generate recommendations (outputs) to support decision-making based on recognized patterns in the way the world <\/span><b><span data-contrast=\"auto\">actually works<\/span><\/b><span data-contrast=\"auto\">,<\/span> <span data-contrast=\"auto\">filling in knowledge gaps with real world data. It\u2019s up to humans then to determine the recommendation\u2019s relevance in a given context.<\/span> <span data-contrast=\"auto\">This makes predictive DSIs powerful tools because they can, at least in theory, be used to predict anything about which the technology collects data\u2014whether that image looks like a tumor, whether a patient is likely to develop a specific disease, or whether a patient is likely to make it to their next appointment, to name a few. In part, because expert clinical guidelines have not been established for many topics, predictive DSIs can provide important guidance on a wide range of topics that evidence-based DSIs currently do not touch. <\/span><a href=\"https:\/\/nam.edu\/artificial-intelligence-special-publication\/\"><span data-contrast=\"none\">At their best<\/span><span data-contrast=\"auto\">,<\/span><\/a><span data-contrast=\"auto\"> predictive DSIs can identify patterns in data earlier or more precisely than health care professionals, or even uncover patterns not previously known, and recommend decisions across many facets of health care.\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-magnifying-existing-risks-resulting-from-emerging-technology-nbsp\"><b><span data-contrast=\"none\">Magnifying Existing Risks Resulting from Emerging Technology\u202f<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/h2>\n\n\n\n<p><span data-contrast=\"auto\">While predictive DSIs have enormous potential to improve many aspects of health care, they also present several potential risks that could lead to adverse impacts or outcomes. These risks may be magnified because of their potential to \u201clearn\u201d rapidly and produce predictions across many hundreds or thousands of patients. In particular, predictive DSIs in health care can:\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b><span data-contrast=\"auto\">Reproduce or amplify implicit and structural biases of society, health, and health care delivery<\/span><\/b><span data-contrast=\"auto\">, as it is captured in the underlying training data. This can lead to predictions or recommendations that are unfair or biased. It could also lead to technology performing differently among certain patients, populations, and communities without the user\u2019s knowledge, potentially leading to patient harm, widening health disparities, <\/span><a href=\"https:\/\/www.federalregister.gov\/d\/2022-16217\/p-979\"><span data-contrast=\"none\">discrimination<\/span><\/a><span data-contrast=\"auto\">, inefficient resource allocation decisions, or poorly-informed clinical decision-making.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n\n\n\n<li><b><span data-contrast=\"auto\">Magnify existing concerns about the ethical, legal, and social implications of underlying data practices (collection, management, and use)<\/span><\/b><span data-contrast=\"auto\">. Whenever health data are collected, managed, and used, there are information privacy, security, and stewardship concerns, including those pertaining to confidentiality, anonymity, and control over the use of information about an individual (potential misuse of information; unexcepted or adversarial use). The potential for predictive DSI to use health data in novel ways heightens these concerns.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n\n\n\n<li><b><span data-contrast=\"auto\">Reinforce common, non-evidence-based practices.<\/span><\/b><span data-contrast=\"auto\"> While bias is a high-profile example of how predictive DSIs might learn and reinforce bad practices, more generally, predictive DSIs may reinforce the tendency to do something a certain way because that\u2019s the way it is always done, even without supporting evidence of benefit. Because predictive DSIs learn from what is commonly done, not necessarily what is best, the use of predictive DSI could slow adoption of new innovations and updated best practices by recommending widespread practices, even after they become obsolete. Cognitive psychology shows that recommendations from predictive DSIs have the potential to reinforce widespread practices by making them the default option (default bias) or because of over-reliance on automation (automation bias).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n\n\n\n<li><b><span data-contrast=\"auto\">Bake-in existing, inexplicable differences in health care and health outcomes.<\/span><\/b><span data-contrast=\"auto\"> Given the widely noted <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/181589?casa_token=VUr6IxALkJkAAAAA:Xw13eCojmuxHkTk5_S6uNJqANjyrwzmIVaFPNQD0HoKzPM6HuG5c8zk3amebEesD1yFrX1OsXg\"><span data-contrast=\"none\">extreme levels <\/span><\/a><span data-contrast=\"none\">of variation in health care<\/span><span data-contrast=\"auto\">, even <\/span><a href=\"https:\/\/digitalcommons.dartmouth.edu\/cgi\/viewcontent.cgi?article=3596&amp;context=facoa\"><span data-contrast=\"none\">across small geographic areas<\/span><\/a><span data-contrast=\"auto\">, directly inferring what will happen <\/span><b><span data-contrast=\"auto\">here<\/span><\/b><span data-contrast=\"auto\"> based on similar patterns in \u201cmessy\u201d real-world data from <\/span><b><span data-contrast=\"auto\">over there<\/span><\/b><span data-contrast=\"auto\"> is a risky proposition. That risk is even greater when the underlying data are of low quality or integrity. This can lead to DSIs making invalid or unreliable predictions, especially if the underlying model makes predictions based on patterns in training data that differ from patterns in data from the local context where the model is used, sometimes referred to as robustness.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b><span data-contrast=\"auto\">Use \u201cblack box\u201d or opaque algorithms so it is impossible to tell exactly how they arrive at a decision<\/span><\/b><span data-contrast=\"auto\">, including how input data are combined, counted, or weighted to produce the model\u2019s prediction, classification, or recommendation. They are also based on predictive algorithms and models that are designed to predict a missing value rather than directly stating an action that should be taken. These facets can reduce the intelligibility of model outputs to end users, making it easy to mis-interpret what a model output means and lead to a greater risk that predictive DSIs are used in settings where they are not appropriate.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n\n\n\n<li><b><span data-contrast=\"auto\">Lead to recommendations that are ineffective or are unsafe<\/span><\/b><span data-contrast=\"auto\">, meaning that the risks described above outweigh any potential benefits.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n\n\n\n<p><span data-contrast=\"auto\">Given that data plays a critical role in predictive DSIs, common data challenges in software development (e.g., quality and integrity) can also directly affect the successful development and use of the predictive DSI. Potential causes of harm may also be due to a lack of or inconsistent governance of data, or policies and controls for how data are acquired, managed, and used across the lifecycle of the predictive DSI.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n\n\n<p><span data-contrast=\"auto\">At ONC, we\u2019ve taken to calling high-quality predictive DSIs that have minimized risks as FAVES: Fair, Appropriate, Valid, Effective, and Safe. We introduced some of these terms in our <\/span><a href=\"https:\/\/healthit.gov\/buzz-blog\/electronic-health-and-medical-records\/getting-the-best-out-of-algorithms-in-health-care\"><span data-contrast=\"none\">first blog post<\/span><\/a><span data-contrast=\"auto\">, and in our next one, we will discuss what we see as a defining challenge inhibiting the optimization of predictive DSIs in health care, and we will discuss ways to know and show that a predictive DSI is FAVES.<\/span><\/p>\n\n\n\n<p>This is part of the Artificial Intelligence &amp; Machine Learning&nbsp;<a href=\"https:\/\/healthit.gov\/buzz-blog\/category\/blog-series-artificial-intelligence-machine-learning\">Blog Series<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>As we\u2019ve previously discussed, algorithms\u2014step by step instructions (rules) to perform a task or solve [&hellip;]<\/p>\n","protected":false},"author":619,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_selected_menu":"","_show_breadcrumbs":"true","_blog_show_featured_image":false,"footnotes":""},"categories":[4,18,22,45],"archived-category":[678],"featured":[],"topics":[405,408,425,416,435],"class_list":["post-22256","post","type-post","status-publish","format-standard","hentry","category-ai-ml","category-electronic-health-and-medical-records","category-health-data","category-privacy-and-security","archived-category-blog-series-artificial-intelligence-machine-learning","topics-artificial-intelligence","topics-care-continuum","topics-hit-policy","topics-safety","topics-security-privacy"],"acf":{"blog_authors":[{"blog_author_profiles":"193015"},{"blog_author_profiles":"198717"},{"blog_author_profiles":"198710"}],"hp_news_hide":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.8.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Two Sides of the AI\/ML Coin in Health Care - ONC Blog<\/title>\n<meta name=\"description\" content=\"Explore the risks and benefits of AI-powered clinical decision support interventions. Understand the potential for bias, data challenges, and effective risk management in health care.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/healthit.gov\/blog\/ai-ml\/ai-ml-in-health-care\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Two Sides of the AI\/ML Coin in Health Care\" \/>\n<meta property=\"og:description\" content=\"Explore the risks and benefits of AI-powered clinical decision support interventions. 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